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NES = 1.60) and mTORC signalling (NES = 1.48) ranked as the top three pathways enriched in patients with poorer outcomes to 5FU-based treatment

This may be advantageous in severe cases of mitochondrial diseases where there could be insufficient ATP available to synthesize glutathione from GGC

Nevertheless, more studies are needed to describe the exact mechanism by which IGF-1 impacts and interacts with other factors and hormones in order to develop each component of MetS, T2D and its cardiovascular consequences

Dosage Requirement Initial glutathione doses at Dermatonik Clinic range from 600 to 1200 mg weekly for 1-2 months, adjusted based on individual response and skin condition