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Watch for worsening pain and spreading redness beyond the immediate area after 48 to 72 hours, fever, a hard warm lump, or systemic allergic symptoms such as hives, facial swelling, throat tightness, or breathing difficulty

This facilitates cell cycle arrest at G 2 /M phase and enables cellular recovery, as observed in Huh-7 cells treated with 20 M curcumin (Sala de Oyanguren et al., 2020)

328 Although setbacks occurred in the phase II study, the combination of ADI-PEG-20 and mFOLFOX6 chemotherapy regimen did not show a significant therapeutic advantage for hepatocellular carcinoma, 239 but there are a small number of subjects who benefit from this regimen