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67 Non-proliferative astrogliosis typically occurs in neural tissue that is responding to a pathology but is not overtly damaged and retains its basic tissue architecture, for example (i) during diffuse neuroinflammation caused by peripheral exposure to microbial antigens such as lipopolysaccharide (LPS), 68,69 (ii) in tissue regions that are at a distance from focal lesions (diaschisis) caused by stroke, trauma or autoimmune attack, 8,70 or (iii) in tissue undergoing neurodegenerative changes

Exfoliation frequently aids in this process, also known as cell turnover

J Clin Transl Hepatol 7(1):5660

That puts the yearly cost around $195 to $510, or about $1,950 to $5,100 over 10 years