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In the world of biology, shape is everything

Semaglutide may worsen diabetic retinopathy in some patients with pre-existing disease, particularly during rapid improvement in glucose control

351 In the process of ferroptosis, cells are affected by oxidative stress and lipid peroxidation, resulting in the rupture of cell membranes and cell death, which is manifested mainly by the reduction in GPX4, the core enzyme of the antioxidant system (glutathione system), and the high expression of the lipid peroxidation marker 4-HNE

The success of tirzepatide may be due to its dual mechanism, which targets multiple receptors