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PGI 2 is released in higher amounts in response to the binding of ligands, such as thrombin, arachidonic acid, histamine or serotonin

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Resection with or without adjuvant radiation therapy is usually considered for localized disease, with cytotoxic chemotherapy reserved for unresectable cases

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New therapeutic strategies focus on MATs approaches, including MitoQ, Mito-TEMPO, and nano-Mito-PBN (Pang et al., 2025

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