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0.1% RGN-259 (thymosin 4) ophthalmic solution promotes healing and improves comfort in neurotrophic keratopathy patients in a randomized, placebo-controlled, double-masked phase III clinical trial

While animal models have demonstrated the therapeutic potential of metabolites, clinical translation is still hindered by pathological complexity and limited understanding of the metabolic effects of current interventions

Most patients reported no impact of therapeutic drug use on work/study, leisure activities or social relationships

The double cta1 ctt1 mutant exhibits hypersensitivity to peroxide during the stationary phase, indicating that both catalases work together to defend against external hydrogen peroxide (Xiao et al., 2018)