Even though the proportion of patients becoming non-self-sufficient is now a validated endpoint for trials in ALS [9], we decided to use the overall survival as primary endpoint based on the results from a previous clinical trial [11]
A randomized, double-blind, placebo-controlled trial in 153 older adults taking the antidepressant citalopram found daily supplementation with 500 g vitamin B 12 , 2 mg of folic acid, and 25 mg of vitamin B6 for one year did not reduce the severity of depressive symptoms but increased the response to drug treatment and helped to prevent symptom relapse (112), suggesting B-vitamin supplementation might provide some benefit as an adjunct therapy
Bodnar LM, Tang G, Ness RB, Harger G, Roberts JM: Periconceptional multivitamin use reduces the risk of preeclampsia
R., Wilson, C., & Wolever, T