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Furthermore, low-grade inflammation of the endothelium is an early event in the pathogenesis of atherosclerotic cardiovascular disease and the GLP-1 analog liraglutide was shown to exhibited anti-oxidative and anti-inflammatory effects, including upregulation of anti-oxidative enzymes and inhibition of nuclear factor kappa B (NF-B)-signaling on endothelial cells (67, 77)

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Bottom Line: The standard protocol (0.25mg 3 days, then 0.5mg 710 days) represents the optimal risk-to-benefit ratio for most research applications