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In PCOS, where OS and IR intersect, MI supplementation restores downstream insulin sensitivity while attenuating ROS generation, a dual action that integrates metabolic correction with redox stabilization ( Experimental and clinical studies collectively reveal that MI modulates cellular redox balance by enhancing antioxidant enzyme activities and reducing oxidative biomarkers such as malondialdehyde (MDA) and nitric oxide derivatives (146, 149, 151)

9 One possible solution to try may be to ensure that fatty acid oxidation (calorie burning) is optimized by supplementing L-carnitine, as many of the dietary sources of L-carnitine may not be appropriate food choices for a low-fat diet