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In humans, GPx4 exists in three alternatively spliced isoforms: cytosolic GPx4 (cGPx4), mitochondrial GPx4 (mGPx4) and sperm nucleus GPx4 (snGPx4) [1, 8]

In asymptomatic adults without red-flag symptoms such as unexplained weight loss, night sweats, pain, or abnormal bleeding, the prevalence of clinically significant, undiagnosed cancer is extremely low

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Binding free energy calculation Among the various available approaches for binding free energy predictions, the molecular mechanics generalized Born surface area (MM/GBSA) method has been suggested to provide the rational results 54,55