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Postmarketing reports have included cases of severe gastrointestinal adverse reactions , including reports of intestinal obstruction and ileus

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Collectively, these mechanisms highlight the dual role of NETs, facilitating immune resolution and tissue repair when tightly regulated, yet perpetuating chronic inflammation when their clearance fails [33, 83]

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Funding This research was supported by Grants CMRPG2M0191, CFRPG2L0021, CMRPG2N0111 and CMRPG2N0041 from Chang Gung Memorial Hospital

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