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In internal metal-detoxification, OAs may chelate with metal in the cytosol, where the ions can be transformed into a non-toxic or less toxic form (Clemens, 2002)

RESERVATION Date Time Cardi Pizzeria Bch ng Cardi Pizzeria Hi An Cardi Pizzeria Nng Cardi Pizzeria V Vn Kit GI

For the E-64d cocrystal structure, where density in the 2 F o F c maps failed to cover all of the ligands aliphatic tail moieties, the pose of the ligand that was best accommodated by the density and gave the lowest R free in refinement was selected and a feature-enhanced 2 F o F c map was calculated in PHENIX from the original reflections and the optimized model to better justify ligand placement 85

Acta Biomed 2014;85(2):108115