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In order to compare the current analysis with the analysis conducted using phase 3 data, a one-compartment model was estimated using data from seven of the clinical pharmacology trials (Table 1) which employed multiple doses of the semaglutide drug product used in the phase 3 trials

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With fatty acids as the main fuel during the nave state [7], effector T cells exhibit a dramatic metabolic switch towards glycolysis upon activation, upregulating glucose transporters and a large spectrum of glycolytic enzymes [8,9]

The weekly injection day may generally be changed when needed, provided there are at least 72 hours between two consecutive doses