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The 72-hour minimum rule The prescribing information for tirzepatide (Mounjaro and Zepbound) states clearly: if you want to change the day of the week you take your injection, you must maintain at least 72 hours (three days) between doses

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Fracture Risk Data from GLP1 Trials Several cardiovascular outcomes trials (CVOTs) have collected fracture data as secondary outcomes: Trials involving semaglutide and dulaglutide generally report fracture rates similar to placebo A few studies suggest a potential increase in non-vertebral fractures, though findings are inconsistent and often not statistically significant One important confounder is weight loss, which itself can lead to bone loss