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In particular, growth hormonerelated peptides (like GHRPs or GHRHs) can increase IGF-1 levels, which some researchers have suggested have the theoretical potential to promote the growth of existing cancer cells

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Dose, route, timing, and model artifacts Preclinical doses (for example, T4 at 630 mg/kg in rats, or BPC-157 at microgram-to-nanogram-per-kilogram ranges) do not translate to humans by simple scaling, and route and timing strongly shaped the reported outcomes

TABLE 2 Pharmacokinetic parameters of berberine-loaded chitosan/SLN nanoparticles and free berberine in rats after a single oral dose administration