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For patients dealing with post-exertional malaise (PEM), the relationship between oxidative stress and physical fatigue is of paramount importance

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Long-term treatment with metformin in obese, insulin-resistant adolescents: results of a randomized double-blinded placebo-controlled trial

SGLT2 inhibitors (sodium-glucose cotransporter-2 inhibitors) such as empagliflozin, dapagliflozin, and canagliflozin represent excellent alternatives, providing cardiovascular and renal protection alongside modest weight loss (typically 2-4 kg)