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The standard protocol escalates gradually over 1620 weeks to minimise gastrointestinal side effects: Your physician may pause escalation at any dose if you are losing weight steadily and tolerating the medication well

During bariatric surgery, surgeons remove parts of the stomach, which can lead to weight loss by reducing appetite-inducing signals related to the hormone ghrelin, which is produced in the stomach

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The duration of treatment may also play a role, with some evidence suggesting that longer treatment periods may be associated with better weight maintenance, though this relationship is not definitively established