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In in vivo xenograft studies, SG3299 eliminated established (100 mm 3 ) Capan-1 PDAC human xenografts and significantly prolonged mouse survival, 103 exemplifying the precision and potential therapeutic impact of v 6 -directed PDCs for pancreatic cancer

As noted in the literature when selecting these targets, reduced levels of IGF1 have been reported in children, adolescents and adults who are autoantibody positive (AAb+) or who have type 1 diabetes [36]

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