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Funding This work was supported by Henan Provincial Department of Science and Technology Key project (NO

Liposomal AKG formula for immunity, longevity, mood balance, and age defense through wrinkle care, bone strength, muscle relief, and mineral uptake

It also raises the available amount of SAMe (S-adenosylmethionine), the important compound which lifts mood and works as a tricyclic antidepressant

As a result, an accumulation of Lipid-OOH occurs: since GSH is the reducing co-substrate of GPX4, able to regulate the redox state of the cell-forming Lipid-OH (Figure 2A), GSH depletion can negatively regulate GPX4, triggering ferroptosis [19]