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In the four months since its launch in the US, tens of thousands of people have reportedly started using the Wegovy pill, with most being new users in the GLP-1 category
While the program doesn't require obesity for approval, individuals with excess weight that affects their daily comfort, mobility, or confidence tend to see some of the most dramatic improvements
If successful in clinical trials and approved, danuglipron could be in a prime position to differentiate based on profile, including full receptor agonism, which we believe has the potential to translate to robust efficacy. However, the company has also announced it will discontinue the clinical development of another GLP-1-RA candidate, lotiglipron, after pharmacokinetic data from Phase 1 drug-drug-interaction studies and laboratory measurements showed elevated transaminases in these Phase 1 studies as well as the ongoing Phase 2 study
