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In clinical trials, tirzepatide demonstrated reductions in hemoglobin A1c of up to 2.5% and weight loss of approximately 15-21% of body weight at higher doses after 72 weeks of treatment, with results varying by dose and patient population

Heatmaps were generated using fold changes

The expression of the luciferase reporter gene was detected according to the instructions of the luciferase reporter gene kit (Promega, E1500), and the detected data were analyzed

People who are pregnant, breastfeeding, or planning pregnancy should avoid retatrutide, along with those who have a personal or family history of thyroid cancer or previous pancreatitis