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They are thought to work in several ways: Your stomach empties more slowly, so you feel full longer after meals Your brain's hunger centers get signals that can reduce appetite Your blood sugar stays more balanced, which can cut down on cravings In a large clinical trial of FDA-approved semaglutide for chronic weight management (Wegovy), participants on the medication plus diet and exercise lost, on average, around 15% of their body weight over 68 weeks

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Tirzepatide is not recommended during pregnancy, particularly when used for weight management, and can reduce the effectiveness of oral contraceptives