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These patients warrant either baseline supplementation or at minimum testing b12 levels every 6 to 12 months during treatment to catch declining levels before deficiency develops

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Enhanced anastomotic strength could reduce leak rates following gastrointestinal surgery, while fistula healing effects might benefit patients with enterocutaneous or colocutaneous fistulas

Taken together, these studies revealed two important principles: (1) that engineering of human IgG1 for improved binding towards FcRn impairs the pH dependency of its interaction with mouse FcRn, causing increased binding also at pH 7.4 and (2) that increased affinity of the IgG Fc:FcRn interaction at pH 7.4 results in a shortened, not prolonged serum persistence of IgG1 Fc fragments [100]