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In a CVOT of an osmotic mini-pump delivering exenatide subcutaneously (ITCA 650) over 36 months, ITCA 650 had a neutral effect on MACE compared with placebo over 16 months [248]

Kong Y, Wang Y, Zhang Y, et al

NEURODEGENERATIVE DISEASES: ALZHEIMERS AND PARKINSONS DISEASES An analysis of the mechanisms of action of GLP-1 and GLP-1RAs indicates that these compounds, by activating GLP-1R, modulate the molecular and cellular changes, and influence the shared processes that determine the phenomenology of neurodegenerative diseases (NDD) and a number of other brain diseases [36]

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