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Similar is the case with enzymes responsible for Phase II metabolism, which also produce detrimental effects on the efficacy of chemotherapeutic agents, owing to overexpression of the enzymes due to prior exposure to the same agents

Most women notice improved sleep quality within 2 to 3 weeks

DSIP had no sleep-inducing effect within the first hour post-injection, but other effects on sleep, such as a significant decrease in the percentage of stage I sleep, reduced awakenings, and increased total sleep time, were significant (t-test), although not significantly from the second to the sixth hour