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Diabetes Obes Metab 20:22382245 Reigner BG, Williams PE, Patel IH, Steimer JL, Peck C, Van Brummelen P (1997) An evaluation of the integration of pharmacokinetic and pharmacodynamic principles in clinical drug development

PIONEER 3 PIONEER 3 compared the efficacy and safety of the addition of oral semaglutide or the DPP-4 inhibitor sitagliptin as add-on therapy in patients with T2DM receiving metformin with or without a sulfonylurea

The MHRA product information for Wegovy notes that these symptoms are typically transient and most pronounced when initiating treatment or increasing the dose

Traditionally, Wegovy has been prescribed as a weekly injection