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LINE-1 RNA causes heterochromatin erosion and is a target for amelioration of senescent phenotypes in progeroid syndromes
FBXW7 contributes to circadian rhythmicity by targeting mTOR, a key regulator of circadian translation, for ubiquitin-mediated degradation, resulting in opposing oscillations between FBXW7 and mTOR protein levels and enabling rhythmic control of translational output (Okazaki et al., 2014
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Several plausible explanations may account for this observation: (i) limited production of MCFAs by the Fas1 mutant
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