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Many individuals use these medications to manage metabolic health even when they arent seeking extreme weight loss

NICE Clinical Knowledge Summaries recommend B12 injections for: Pernicious anaemia an autoimmune condition affecting intrinsic factor production Malabsorption syndromes including coeliac disease and inflammatory bowel disease Post-surgical states particularly following gastrectomy or ileal resection Strict vegan diets when oral supplementation proves inadequate, though oral cyanocobalamin is usually sufficient for dietary deficiency Clinical trials demonstrate that B12 injections rapidly improve haematological parameters and neurological symptoms when deficiency is confirmed through blood tests

Even if GLP-1 drugs are successfully removed from and remain off the FDA shortage list for any substantial period of time, compounders may be able to legally continue offering compounded GLP-1 products so long as they are modified in some way to meet an individual patient need, for example by adding a B vitamin or personalising the dosage (Palmer & Florko, 2024)

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