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In the PIONEER 6 study, oral semaglutide demonstrated CV safety by showing a nonsignificant 21% reduction in the risk of major adverse CV events (MACE), including nonfatal myocardial infarction and stroke, compared to placebo

17 GSTs catalyze glutathionylation or S-glutathionylation, a reversible posttranslational modification regulating protein function, which is significantly promoted by reactive nitrogen species and reactive oxygen species (ROS)

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Unopened pens should be stored in the refrigerator at 36F to 46F (2C to 8C) and should never be frozen