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ROS induces the activation of mitogen activated kinase (MAPK), downregulates the phosphorylation level of extracellular regulatory protein kinase (p-ERK), upregulates activated nuclear transcription factor (NF-KB), activates autophagy pathway, and leads to apoptosis of retinal photoreceptor cells

Aging 10 (2), 197211

AOAC Int

Once acetaminophen metabolizes in the liver by conjugation with glucuronic acid (4067%), sulfuric acid (2046%), and p -aminophenol, it easily crosses the blood-brain barrier and is converted to AM404 ( N -hydroxylation in the liver with the involvement of cytochrome P450 enzymes (especially CYP2E1) to form the toxic metabolite, NAPQI ( N -acetylcysteine must be ingested as soon as possible