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These pathways remain early-stage research targets

Bioavailability differences between delivery methods are significant, with injectable applications achieving tissue concentrations 10-20 times higher than topical applications

We also proposed to update and apply the proposed efficiency adjustment with a cadence of every 3 years to align with the other updates under the PFS, including updates to the Geographic Practice Cost Index (GPCI) and Malpractice (MP) RVUs, and explained that this would allow for streamlining so that interested parties can expect updates on a similar timeframe

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