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Long-term systemic use is concerning for copper balance, as copper deficiency has been linked to neurodegenerative disorders and even excess copper is risky

Hormone-balancing supplements and essential nutrients like healthy fats can be a proactive step in addressing these hormonal challenges

POLG-related disorders should be suspected in patients with a family history or suggestive symptoms of a POLG-related disorder, including but not limited to unexplained encephalopathy, refractory epilepsy (focal, myoclonic), status epilepticus at presentation, developmental delays, psychomotor regression, axonal sensorimotor neuropathy, myopathy cerebellar ataxia, ophthalmoplegia, or complicated migraine with occipital aura

Les tudes cliniques montrent des effets modestes et variables