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Aggressive tumors often overactivate FAK signaling to invade tissue, and they rely on new blood vessels to feed a growing tumor

In contrast with adaptive immunity, which encompasses antigen-specific responses by T and B lymphocytes, trained immunity is characterized by antigen non-specific tissue adaptation to acute and chronic inflammation, sometimes in response to infection, and has been predominantly studied in professional innate immune cells such as macrophages, monocytes, dendritic cells and natural killer cells 23,24,25

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Cancer 12 , e007990 (2024)