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During niacin treatment, fasting glucose, insulin and HOMA1-IR (insulin resistance score based on blood glucose and insulin) increased in some individuals up to 1.9-fold after niacin dose of 500 mg, suggesting increased insulin resistance (Fig
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Although this study did not directly validate causality by modulating DRP1 or OPA1, our previously published research 12 confirmed that targeted regulation of DRP1 or OPA1 effectively modulates neuropathic pain, indicating that resveratrol may alleviate neuropathic pain by improving mitochondrial function, potentially via the regulation of mitochondrial fission and fusion balance in the CCI model
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