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References to food supplements have not been evaluated by the EFSA (European Food Safety Authority) and are not intended to diagnose, treat, cure, or prevent any disease

Pichler, J

Besides, estradiol and estrone can be interconverted by 17-hydroxysteroid dehydrogenase, and estriol is primarily produced from the other two during pregnancy ( Estrogen exerts its effects via the classic nuclear receptors, estrogen receptor alpha (ER) and estrogen receptor beta (ER), as well as novel membrane-associated receptors, G protein-coupled receptor 30, Gq protein-coupled estrogen receptor, and ER-X

the Taiwan Food and Drug Administration which granted it Breakthrough Designation in September 2024