Our guide on tirzepatide not working anymore covers this scenario and other reasons for efficacy loss
GLP-1 initiation was driven primarily by nurse practitioners (28.0%), family medicine providers (22.4%), endocrinologists (16.3%), internal medicine providers (11.1%), and physician assistants (10.3%), while OB/GYN providers accounted for 5.5%
However, it also did not look at the effects of aspirin particularly looking at patients taking other medications that would put them at a higher risk for bleeding, or in patients with known gastrointestinal disorders, such as ulcers or gastritis. It would be interesting to compare lifestyle modifications such as diet, exercise and sleep compared to just taking aspirin alone, in regards to developing type 2 diabetes
Anecdotal human reports of cycles lasting 8 to 16 weeks describe no severe adverse events in the majority of accounts, but self-reporting bias and the absence of laboratory monitoring limit the reliability of the community safety record