In T2D patients (n = 25, age 2565), consumption of 1 g L-citrulline twice a day for 4 weeks reduces the T2D-induced increase in arginase activity and increases plasma nitrites, effects corroborated by improvement of ACh-induced relaxation in ex vivo mouse aortic rings incubated (24-h) in low or high glucose-containing media and increases in NO production in ECs treated with high glucose (Shatanawi et al., 2020)

for PWS patients ages 4 years and older strict food control and constant supervision when food is accessible a well-balanced, low-calorie PWS diet and frequent exercise to aid in weight management Supportive care for PWS may also involve, but is not limited to: tube feeding, to provide adequate nutrition to infants sex hormone replacement therapy in PWS, to address low levels of sex hormones (testosterone in boys and estrogen and progesterone in girls) sleep management, including medications to reduce excessive daytime sleepiness therapeutic strategies, including surgery, to correct orthopedic issues like scoliosis physical and occupational therapy to combat low muscle tone and motor delays speech therapy to improve verbal skills medications or behavioral therapy for PWS to manage mood and behavior problems Lifestyle changes PWS management may also involve a range of lifestyle changes, typically implemented or promoted by parents, to minimize how intrusive PWS symptoms become in daily life

This remains the foundational cardiovascular dataset referenced in 2026 protocol design (flagged as pre-2023 foundational data)
Available from www.training.cochrane.org/handbook