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Preclinical models commonly use doses ranging from 100mcg to 500mcg per administration, with frequency varying from daily to twice-weekly depending on the biological pathway under investigation

Eating habits and meal timing significantly impact symptom severity: Consume smaller, more frequent meals rather than large portions, as this reduces the burden on an already-slowed digestive system

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Where Phase 2 Left Off The Phase 2 trial of Retatrutide published in The New England Journal of Medicine (Jastreboff et al., 2023) was a 48-week, randomised, double-blind, placebo-controlled dose-ranging study in adults with obesity (BMI 2750) without type 2 diabetes