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While certain tumor cells, like MDA-MB-231 cells, display positive durotaxis by moving from soft (0.5 kPa), to stiff (22 kPa) substrates [95, 96], others, such as U-251MG glioblastoma brain tumor cells, undergo negative durotaxis, migrating from 22 kPa regions towards softer, 10 kPa, areas [96]
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Tirzepatide, a dual GLP-1/GIP receptor agonist has been approved for glycaemic control in type 2 diabetes as well as for obesity management leading in up to 22.5% WL in phase 3 obesity trials
Escalate: Increase by 24 mg every 4 weeks as tolerated
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