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By screening transcription factors expressed during remyelination, these authors are able to identify the WNT signalling pathway as a potent negative regulator of progenitor differentiation during myelination and remyelination, spawning a series of further studies

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Some of these observations provide the basis for the neurotrophic hypothesis of depression which associates decreased BDNF expression with depression and increased BDNF expression with antidepressant action, 20 effects possibly mediated by alterations in neurogenesis

It includes a boxed warning for thyroid C-cell tumors, based on rodent data, and it is contraindicated in people with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN2)