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Efficacy and safety of low-dose otelixizumab anti-CD3 monoclonal antibody in preserving C-peptide secretion in adolescent type 1 diabetes: DEFEND-2, a randomized, placebo-controlled, double-blind, multi-centre study

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Although it is not clear whether BBB disruption and -synuclein pathology are the cause or the result of inflammation, an ongoing inflammatory state will stimulate endothelial cells to contract, leading to a porous rebuilding of the endothelial cell layer [154]