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Abbreviations CBS: Cystathionine -synthase CSE: Cystathionine -lyase Sal A: Salvianolic acid A SAM: S-adenosylmethionine SAH: S-adenosylhomocysteine GSH: Reduced glutathione GSSG: Oxidized glutathione Cys-Gly: Cysteinyl-glycine GCL: Glutamate-cysteine ligase LDL: Low density lipoprotein MS: Methionine synthase BHMT: Betaine homocysteine methyltransferases MTHFR: Methylenetetrahydrofolate reductase ROS: Reactive oxygen species