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Any switch should be clinician-directed

Although the signal for its intended outcomes was positive, public fervor for the drug diminished when the FDA ultimately rejected approval in the United States because of an increased risk of adverse psychiatric outcomes in the treatment group, including two deaths by suicide

Sensitivity analyses To assess the robustness of our findings, we conducted a subgroup analysis by grouping RCTs by seven primary outcome categories (e.g., Parkinsons disease, Alzheimers disease, Lewy body dementia, multiple sclerosis, amyotrophic lateral sclerosis, frontotemporal dementia, and Huntingtons disease)

If they do, the market will return to its monopolistic state after a brief stint where patients had access to lower-cost alternatives to Novos Ozempic and Wegovy