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Legitimate peptide synthesis requires expensive materials, specialized equipment, and quality control testing

Therefore, compared to the passive delivery of traditional particles and preparations, MNMs can achieve the same therapeutic effect with a lower drug concentration

D1R D1R signaling participates in the negative regulation of the activation of NLRP3 inflammasome, which can be assembled upon stimulation with accumulated endogenous metabolites such as fibrillar amyloid and 25-hydroxycholesterol (113), the subsequent secretion of caspase-1 and IL-1 contributes to the destruction of dopaminergic neurons (114)

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