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5,288,289 Oxidative Stress Free radicals, especially oxidized low-density lipoprotein (LDL), promote vascular inflammation, increase the expression of tissue factor on cellular surfaces, damage proteins that regulate coagulation, heighten reactivity of platelets, and disrupt antithrombotic hemostatic mechanisms, raising the risk of thrombosis

Pyridoxine (Vitamin B6) is essential for amino acid metabolism, neurotransmitter synthesis, and haemoglobin production

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Hence current advice is aimed at symptom management and lifestyle changes ( Figure 12