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Pharmacokinetic Challenges: Researchers determined that the reason for GLP-1s fleeting presence is rapid enzymatic degradation

6 As energy content and macronutrient composition of the meals provided in our study varied across the day, our results do not warrant conclusions on whether the timing of meals, in addition to meal size, 13 regulates the magnitude of the GLP-1 response

It can be broken down through glycolysis, a rapid process that does not require oxygen and that yields ATP quickly, though not in large quantities

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