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RAW 264.7 cells exhibited significantly greater chemotaxis toward mEPs excreted by tendon constructs receiving 9% strain (mEP 9% ) than those excreted by tendon constructs receiving mEP 0% , mEP 3% or mEP 6% , which was consistent with previous reports showing that overload could induce significant macrophage infiltration and tendinopathy 2,39

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Traditional systemic administration of anti-ferroptotic agents often faces poor ocular bioavailability and non-targeted toxicity