glp-1 drugs pcos GLP-1s and PMOS: PCOS, Insulin Resistance, and Weight Loss Taking a GLP-1 for PCOS

J Appl Physiol 63 : 152157 Rahman I, Mulier B, Gilmour PS, Watchorn T, Donaldson K, Jeffery PK, MacNee W 2001 Oxidant-mediated lung epithelial cell tolerance: the role of intracellular glutathione and nuclear factor-kappab

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(Left) In liver cells, GLP-1 can mediate cholesterol efflux by acting directly on LXR, or by inducing an increase in ATP-binding cassette transporter A1 (ABCA1) mRNA through Ca2+/calmodulin (CaM)-dependent protein kinase kinase/CAM-dependent protein kinase IV/Prolactin regulatory element binding (CaMKK/CaMKIV/PREB), increasing apolipoprotein AI (apo AI) mRNA and promoter expression, and increasing apo AI secretion, thereby mediating intracellular cholesterol efflux