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(1) Also known as GLP-1 RA (receptor agonists), semaglutide and tirzepatide work by hindering the release of glucagon , the hormone that increases blood sugar

Absorption into the CNS after intranasal administration has been postulated to occur via the olfactory and trigeminal neuronal pathways (intraneuronal) and diffusion across mucosal barrier and olfactory plate (extraneuronal), depending on the size, polarity, and odorant nature

Post-marketing surveillance and case reports have documented instances of acute pancreatitis in patients taking these medications, prompting regulatory agencies to investigate the association

doi: 10.3390/ijms26189065 62 HillC.GuarnerF.ReidG.GibsonG