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All patients should reduce premeal insulin by 50% to lessen the risk of insulin-induced hypoglycemia, monitor blood glucose frequently, and contact their health care provider if symptoms of nausea and/or hypoglycemia are severe or unusually persistent and when the dosage of pramlintide or insulin is changed

(2) Allow Modifications to the Certified ACO Participant List for ACO Participant CHOWs During a Performance Year As we described in the CY 2026 PFS proposed rule (90 FR 32660 through 32661), we recognize that requiring ACOs to wait until the upcoming change request cycle each performance year to update their certified ACO participant list to reflect an ACO participant's CHOW can, in some cases, present operational difficulties for ACOs

AEs were assessed at week 75

The weekly dosing frequency maintains steady levels of the medication in the body to suppress appetite, promote blood sugar control, and reduce body weight